Welcome to the Shook Lab
The Shook Lab is housed within the Department of Biochemistry and Molecular Medicine at The George Washington University School of Medicine and Health Sciences in Washington, D.C.
Altered immune responses are a leading cause of aberrant tissue inflammation, impaired repair and tissue dysfunction. Our lab focuses on how skin-resident fibroblasts and adipocytes communicate with immune cells after injury and during inflammatory diseases. We focus on cellular and molecular mechanisms of stromal cell immunogenicity and how these mechanisms are altered in diseases associated with altered inflammation. Our goal is to identify targetable pathways that can be used for diagnostic or therapeutic treatment of tissue inflammation.